News

Cardiff Cancer Research Open Day

Cardiff University’s European Cancer Stemcell Research Institute, Velindre NHS Trust and Cancer Research UK  will be holding a Cancer Research Open Day on Saturday 24th October at the Hadyn Ellis Building, Maindy Road (posters attached).

This public event will showcase the diverse, cutting-edge cancer research taking place across Cardiff and attendees from across Wales are welcome. The event is aimed primarily at members of the public but visitors will meet cancer scientists, doctors and nurses, go behind the scenes on lab tours, learn about local research through talks and interactive demos and create some biological artwork with local textile artist, Lisa Porch.

Attendance is free and visitors can register their interest at https://www.eventbrite.co.uk/e/cardiff-cancer-research-open-day-2015-tickets-18114580197.

For further information please see the attached posters.

Cancer research open day 2015 poster Welsh

Cancer research open day 2015 poster English


Longitude Prize

£10m to conserve antibiotics for future generations

Thursday 24th September

18:00-20:00, Life Sciences Hub, 3 Assembly Square, Cardiff. Wales. CF10 4PL

Refreshments will be provided

Nesta and Life Sciences Hub Wales would like to invite you to come and find out more about the £10m Longitude Prize’s fascinating 300-year history, last year’s BBC Horizon vote and what you need to do to win the Prize.
The Longitude Prize is a historic challenge that aims to conserve antibiotics for future generation. The challenge is to develop a cheap, accurate, rapid and easy-to-use, point-of-care test that will identify when antibiotics are needed and, if they are, which ones to use.

The Longitude Prize was opened last year and will run until December 2019 or until a winner is found.

Find out more about how to win the Longitude Prize – sign up now

The event will be hosted by Adam Price

You will hear from:

Dr Tracey Cooper

Chief Executive – Public Health Wales

Professor Chris Butler

Professor of Primary Care Medicine and Longitude Prize Judging Panel member

Professor Jim McLaughlin OBE

Professor in the University of Ulster School of Engineering & Chief Technology Officer – Zensor

Reserve your place now

 

 

 


Crowdfunding for Research in Life Sciences

Cardiff University are looking to support a number of research projects through innovative crowdfunding company FutSci. Crowdfunding, in its simplest form, is a way of raising funds by asking a large number of people to contribute a relatively small amount of money. Futsci specialises in funding biomedical research through crowdfunding and provide the opportunity for individual to support specific research projects.

For more information, please visit their website, https://www.futsci.com


MEP-Scientist Pairing Scheme 2015

The European Parliament is issuing an invitation for academics to take part in the ‘MEP-Scientist Pairing Scheme 2015’.  The EU recognise the importance of scientific expertise in informing policy-maker dealing with global challenges, from climate change to feeding the world, from an ageing population to energy security.  The MEP-Scientist Pairing Scheme provides an opportunity for scientists to influence policy makers and gain a better understanding of the EU science, technology and research policy framework.
Interested parties should download the application form for more details (website).  Please note that the deadline for application is the 31st of July 2015.

AMR

Anti Microbial Resistance

Antimicrobial resistance is a growing public health issue that threatens to undermine the treatment of an increasing range of infections caused by bacteria, viruses and fungi. Many of the most commonly used antimicrobials are becoming less effective with bacteria, viruses and fungi naturally adapting and becoming increasingly resistant to medicines used to treat the infections they cause.

This is a global problem that the Work Economic Forum and World Health Organisation have both identified as a major public health problem.

The issue has also been raised by the UK’s Chief Medical Officer and resulted in the Department of Health releasing a Five Year Antimicrobial Resistance Strategy (2013-18).

Academics from across Wales have a long track record of research into antimicrobial resistance and are working together to address key challenges in the following areas:

Alternative Approaches to Treating Bacterial Infection
Development of Novel Therapeutics
Development of Diagnostic Devices.
The consortium includes members from the following Welsh universities:

Aberystwyth, Bangor, Cardiff and Swansea.

If you are interested in joining the forum or finding out more, please email us nrn@cardiff.ac.uk


Recently funded Research Projects and Studentships

The Network has recently awarded the following Round 3 Research Projects and Studentships:

Research Projects:

Dr Gwenin, A rapid point of care system to manage/monitor drug treatment in therapeutically relevant mycobacterial infections

Prof O’Donnell, Development of new prothrombotic lipids for haemostatic applications

Prof Hall, Investigating the potential of the sphingosine-1-phosphate receptor 1 modulators for the treatment of psychiatric disorders.

Prof Piguet, Anti-viral activity of ProTide derivatives on human T cells

Dr Rozanowska, Novel modulators of the visual cycle for treatment of retinal degenerations

Dr Kidd, Investigating a novel therapy for Alzheimer’s disease in a mouse model of amyloid pathology

Dr Clarkson, Sensitizing to radiotherapy: ore-clinical evaluation of a novel indication for adjuvant bcl3i

Prof Dale, Establishing a screen for the WNT-STOP mitotic signalling pathway

Prof Wilkinson, Expression and activity determination of novel cloned antibiofilm peptides

Dr Westwell, Advancing analogues of a novel cFLIP inhibitor which sensitises breast cancer cells and cancer stem cells to TRAIL

Studentships:

Dr Heard, Towards the repurposing existing of topical antimicrobials by ligand complexation.

Prof Hoffmann, Repositioning histone methyltransferase inhibitors as next generation anthelmintics.

Prof Mur, Exploiting natural products from Hops (Humulus lupulus) to suppress tuberculosis.

Prof Sheldon, Manipulation of squalene synthase to limit bacterial infections.

Dr Howell, Treating Progressive Multiple Sclerosis Using A Novel Neuroprotective And Anti-Inflammatory approach.

Dr Del Sol, Companion diagnostic development guides Antibody-Drug Conjugate formulation: Implications for patient stratification and precision medicine.

Dr Cai, Combining carbon monoxide (CO)-releasing molecules with anti-VEGF therapy for triple-negative breast cancer therapy.

Prof Doak, Design and evaluation of an antibody-drug conjugate for prostate cancer treatment.

Prof Brophy, Towards validation of an immune suppressor protein from liver fluke as a drug target.

Prof Triantafilou, Peptides derived from Yersinia pestis V antigen as novel therapeutic interventions for sepsis.

Prof Doak, Mechanistic evaluation of the impact of superparamagnetic iron oxide nanoparticles conjugated with drugs (SPIONd) on intracellular signalling/homeostatic mechanisms.

Dr Creevey, Computational approaches to mining the rumen micro biome for novel antimicrobials.

Dr Gwenin, Testing a novel chemotherapy delivery system using two dinitrobenzamide mustard prodrugs.


European Institute of Innovation Technology (EIT) partnership workshop on diet, metabotypes and healthy living

The Life Science Research Network is supporting an European Institute of Innovation Technology (EIT)  partnership workshop on diet, metabotypes and healthy living next Tuesday the 19th of May in the Life Science Hub at Cardiff Bay.   This event is being led by Aberystwyth University and will be of most value to individuals and businesses interested in bringing new health innovations in precision nutrition and diagnostics to market. The event is open to all but places are limited. For further information, please contact Lia Tseki at evt3@aber.ac.uk.
EIT Health (http://eit.europa.eu/eit-community/eit-health) is the newly designated Knowledge and Innovation Community (KIC) for Healthy Living and Active Ageing. KICs are a unique type of partnership within the European innovation landscape and develop innovative products and services, foster new business, encourage growth, and train a new generation of entrepreneurs. Characterised by a high degree of integration, a long-term perspective, efficient governance, the co-location model and an entrepreneurial culture, KICs aim to increase Europe’s capacity for innovation by bringing together leading companies, universities, and research labs.

 


Tackling AMR Theme 2: Accelerating therapeutic and diagnostics development

The AMR cross-council initiative has launched a new call under theme  2 –  “Accelerating therapeutic and diagnostic development”.

MRC, BBSRC, EPSRC, and ESRC are supporting this call and the MRC is managing it on behalf of the funding partners.

The focus of the call is to:

  • Refresh the pipeline for human and animal antibiotics;
  • Develop new non-drug based treatments for bacterial infections (vaccines, immunotherapies, probiotics, prebiotics, phages, amongst others);
  • Improve the efficacy of existing drugs through effective dosing strategies to minimise development of resistance and/or develop more targeted delivery methods;
  • Accelerate the scale-up and manufacture of novel antibiotics and vaccines;
  • Underpin the development of rapid, point of care diagnostics to enable the most appropriate therapy/intervention to be chosen;
  • Develop innovative diagnostics data linkages for community settings to monitor spread; and
  • Consider the real world issues that will affect the development and utilisation of new treatments and diagnostics

Partnership between industry and academia is actively encouraged under this initiative.

The call has two funding modes:

  • Collaborative grants – ~£3m each for 4-5 years, multidisciplinary in nature across more than one research organisation
  • Innovative grants – ~£200k each over 12-24 months, highly innovative, high risk/high gain

Deadline for submission is 4 June 2015.

Please circulate widely to your communities and direct them to this webpage:

http://www.mrc.ac.uk/funding/browse/tackling-amr-theme-2-accelerating-therapeutic-and-diagnostics-development/

For queries:

MRC: Ghada Zoubiane / Ruth Kelly amr@headoffice.mrc.ac.uk

BBSRC: Sian Rowland: amr@bbsrc.ac.uk

EPSRC: Victoria Marlow: healthcare@epsrc.ac.uk

ESRC: Naomi Beaumont: Naomi.Beaumont@esrc.ac.uk


Record Number of Applications Received

Our call has now closed and we have received and acknowledged a record number of applications – 83 in total! Thank you for applying.

For information, the board will be meeting on 29th and 30th April to discuss applications and award successful ones.

If you have any queries in the mean time, please contact us nrn@cardiff.ac.uk

 


Life Sciences Bridging Fund Scientific Advisory Board: Appointment of Chair and Members

The new £3m life sciences bridging fund, established in March 2015, will create commercial opportunities from Welsh life sciences research projects, stimulating further growth in the sector. The fund will be managed by the Life Sciences Hub Wales and will support up to 25 research projects over 3 years.
The Scientific Advisory Board will be responsible for the administration, governance, management and delivery of the fund and will report to the Life Sciences Hub Board who will be responsible for providing oversight of the fund.

Welsh Government, on behalf of the Life Sciences Hub Wales, is seeking applicants with an interest in, knowledge and experience of the life sciences sector, in particular research and commercialisation; technology transfer, academia and commercial exploitation of life sciences research.

Background to the Fund:
http://gov.wales/newsroom/businessandeconomy/2015/9877571/?status=closed&lang=en

Closing date: 15 April 2015

Further details and application information can be found at: http://www.lifescienceshubwales.com/news/life-sciences-bridging-fund-scientific-advisory-board-appointment-of-members/